Effect of Acarbose on Blood Sugar Levels in Male White Rats (Rattus norvegicus) With Pathologies of Liver Dysfunction and Renal Dysfunction
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Abstract:
Background of study: Diabetes is caused by metabolic disorders that result in high blood glucose levels due to insulin deficiency and insulin resistance. This disease can trigger serious psychological, social, and physical problems and increase the risk of kidney and liver disease. Insulin resistance exacerbates liver damage through hyperinsulinemia and oxidative stress, which also affects kidney function. Research on acarbose suggests its potential to reduce diabetes complications, including liver and kidney dysfunction.
Aims and scope of paper: This study aims to determine the effect of acarbose on blood glucose levels in diabetic rats with induced liver and kidney dysfunction using an in vivo experimental model.
Methods: This study is an in vivo experiment using a male white rat (Rattus norvegicus) as a subject. The study began with acclimatization of mice, followed by induction with aloxan, CCl4, and gentamicin, and observation for 7 days. After that, the mice were given acarbose suspension according to the test group, and blood samples were analyzed.
Result: The results showed that acarbose was effective in lowering blood sugar levels in diabetic and liver-dysfunction mice, but had no effect in kidney-dysfunction mice because there was no kidney damage.
Conclusion: acarbose significantly lowered blood sugar levels in mice with diabetes and liver dysfunction, but not in those with kidney dysfunction.
Keywords: aloxane, blood sugar level, creatinine, sgpt, acarbose
Copyright (c) 2025 Sry Nur Admidha, aisa dinda mitra, Mohammad Qais Rezvani
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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