The Relationship Between Clinical And Anthropometric Factors And Diabetic Neuropathy In Type 2 Diabetes Mellitus Patients At Primary Healthcare Facilities

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Published: Apr 20, 2026

Abstract:

Background: Diabetic neuropathy is a chronic complication commonly occurring in type 2 diabetes mellitus patients and serves as the primary cause of foot ulcers and amputations. In primary healthcare facilities, early detection of neuropathy faces limitations in resources and diagnostic tools. Therefore, identifying easily measurable clinical and anthropometric factors is crucial to support initial screening in at-risk populations.


Aims and Scope of the Paper: This study aims to analyze the relationship between clinical factors and anthropometric parameters with the incidence of diabetic neuropathy in patients with type 2 diabetes mellitus at primary healthcare facilities. The scope of the study includes the evaluation of variables such as age, gender, duration of diabetes, random blood glucose levels, blood pressure, and body mass index (BMI).


Methods: This study employed an analytic observational design with a cross-sectional approach. A total of 120 patients with type 2 diabetes mellitus were recruited using purposive sampling. Diabetic neuropathy was assessed using the monofilament test. Independent variables included body mass index (BMI), duration of diabetes, and hypertension status. Data analysis was performed using the chi-square test with calculation of prevalence ratios (PRs) and 95% confidence intervals (CIs).


Results: Of the 120 respondents, 78 (65.0%) were diagnosed with diabetic neuropathy. Overweight/obese BMI was significantly associated with neuropathy (PR = 4.39; 95% CI: 2.17–8.89; p < 0.001). Diabetes duration of more than 5 years also demonstrated a significant association (PR = 2.27; 95% CI: 1.35–3.83; p = 0.002). Hypertension was significantly associated with diabetic neuropathy (PR = 2.91; 95% CI: 1.58–5.36; p < 0.001).


Conclusion: Overweight/obese BMI, longer duration of diabetes, and hypertension were significantly associated with diabetic neuropathy in patients with type 2 diabetes mellitus at primary healthcare facilities. These simple clinical and anthropometric parameters can be utilized as a basis for risk screening in the early detection of diabetic neuropathy in primary care settings.

Keywords: Diabetic Neuropathy, Body Mass Index (BMI), Duration Diabetes, Hypertension, Primary Health Care

Authors:
1 . Maria Karolina Selano
2 . Emirensiana Anu Nono
3 . Kristiana Prasetia Handayani
4 . Maria Dolorosa Peni Sogen
5 . Gregorius Tsiompah
How to Cite
Selano, M. K., Nono, E. A., Handayani, K. P., Sogen , M. D. P., & Tsiompah, G. (2026). The Relationship Between Clinical And Anthropometric Factors And Diabetic Neuropathy In Type 2 Diabetes Mellitus Patients At Primary Healthcare Facilities. Journal of Nursing Management Innovations, 2(1). https://doi.org/10.58723/jnmi.v2i1.80
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Copyright (c) 2026 Maria Karolina Selano, Emirensiana Anu Nono, Kristiana Prasetia Handayani, Maria Dolorosa Peni Sogen , Gregorius Tsiompah

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Research Articles

References

Apriliany, F., Cholisah, E., & Erlianti, K. (2022). Efek pemberian metformin dan metformin+ glimepiride terhadap kadar HbA1c pada pasien diabetes mellitus tipe 2. DOI: https://doi.org/10.22146/jmpf.72192

Amelia, R., Harahap, J., Yunanda, Y., Wijaya, H., Fujiati, I. I., & Yamamoto, Z. (2021). Early detection of macrovascular complications in type 2 diabetes mellitus in Medan, North Sumatera, Indonesia: A cross-sectional study. F1000Research, 10, 808. DOI: https://doi.org/10.12688/f1000research.54921.2

Callaghan, B. C., Gallagher, G., Fridman, V., & Feldman, E. L. (2020). Diabetic neuropathy: what does the future hold?. Diabetologia, 63(5), 891-897. DOI: https://doi.org/10.1007/s00125-020-05085-9

Carmichael, J., Fadavi, H., Ishibashi, F., Shore, A. C., & Tavakoli, M. (2021). Advances in screening, early diagnosis and accurate staging of diabetic neuropathy. Frontiers in endocrinology, 12, 671257. DOI: https://doi.org/10.3389/fendo.2021.671257

Cho, Y. K. (2023). Waist circumference and body mass index variability and incident diabetic microvascular complications: a post hoc analysis of ACCORD Trial (Diabetes Metab J 2022; 46: 767-80). Diabetes & Metabolism Journal, 47(1), 147-149. DOI: https://doi.org/10.4093/dmj.2022.0435

Contesa, A., Malini, H., & Rahman, D. (2024). Faktor Resiko Diabetic Peripheral Neuropathy Pada Pasien Dm Tipe II. Prepotif: Jurnal Kesehatan Masyarakat: Universitas Pahlawan Tuanku Tambusai, 8(2), 3725-3732. DOI: https://doi.org/10.31004/prepotif.v8i2.28904

Davalos, L., Callaghan, B. C., Muthukumar, L., Thomas, S., Reynolds, E. L., Smith, A. G., ... & Stino, A. M. (2025). The impact of diabetes and metabolic syndrome burden on pain, neuropathy severity and fiber type. Annals of Clinical and Translational Neurology, 12(7), 1408-1417. DOI: https://doi.org/10.1002/acn3.52382

Faiqotunnuriyah, F. (2021). Faktor Risiko Neuropati Diabetik pada Penderita Diabetes Melitus Tipe 2. Kesmas Indonesia, 13(1), 64-76. DOI: https://doi.org/10.30597/kesmas.v13i1.12154

Gao, S., Zhang, H., Long, C., & Xing, Z. (2021). Association between obesity and microvascular diseases in patients with type 2 diabetes mellitus. Frontiers in Endocrinology, 12, 719515. DOI: https://doi.org/10.3389/fendo.2021.719515

Husna, C., Akmal, A., Syarif, H., & Agustina, S. (2024). Exploring the connection between diabetes duration, HbA1c levels, and peripheral neuropathy in type 2 diabetes patients. International Journal of Advanced and Applied Sciences, 11(4), 236-240. DOI: https://doi.org/10.21833/ijaas.2024.04.025

Jensen, T. S. (2023). The pathogenesis of painful diabetic neuropathy and clinical presentation. Diabetes research and clinical practice, 206, 110753. DOI: https://doi.org/10.1016/j.diabres.2023.110753

Joni, A. S. D., Mangarengi, Y., Ansary, S. N., Nur, M. J., & Muchsin, A. H. (2025). Profil Neuropati Perifer Berdasarkan Skor Pain DETECT pada Penderita Diabetes Melitus Tipe 2 yang Menggunakan Metformin di Puskesmas Unaaha. Borneo Journal of Medical Laboratory Technology, 7(2), 653-665. DOI: https://doi.org/10.33084/bjmlt.v7i2.8398

Kaur, M., Misra, S., Swarnkar, P., Patel, P., Kurmi, B. D., Gupta, G. D., & Singh, A. (2023). Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies. Biochemical pharmacology, 215, 115723. DOI: https://doi.org/10.1016/j.bcp.2023.115723

Kusnadi, D. T., & Zulkarnaini, A. (2022). the Karakteristik Faktor-faktor Risiko Terjadinya Neuropati Diabetik pada Pasien Diabetes Melitus tipe 2 di RSI Siti Rahmah Padang Tahun 2019-2020: Karakteristik faktor-faktor risiko terjadinya neuropati diabetik. Scientific Journal, 1(2), 96-102. DOI: https://doi.org/10.33856/scij.v1i2.235

Luo, L., Long, X., Cheng, C., Xu, Q., & Li, J. (2024). Development and validation of a risk nomogram model for predicting peripheral neuropathy in patients with type 2 diabetes mellitus. Frontiers in endocrinology, 15, 1338167. DOI: https://doi.org/10.3389/fendo.2024.1338167

Nashtahosseini, Z., Eslami, M., Paraandavaji, E., Haraj, A., Dowlat, B. F., Hosseinzadeh, E., ... & Naderian, R. (2025). Cytokine signaling in diabetic neuropathy: a key player in peripheral nerve damage. Biomedicines, 13(3), 589. DOI: https://doi.org/10.3390/biomedicines13030589

Nistiandani, A., Sulistyorini, L., Fauziah, N., & Fakhrur Rozsy, M. (2019). Characteristic Of Demographic Neuropathy Diabetic Perifer In The Agriculture Area.

Pfannkuche, A., Alhajjar, A., Ming, A., Walter, I., Piehler, C., & Mertens, P. R. (2020). Prevalence and risk factors of diabetic peripheral neuropathy in a diabetics cohort: Register initiative “diabetes and nerves”. Endocrine and Metabolic Science, 1(1-2), 100053. DOI: https://doi.org/10.1016/j.beem.2020.100053

Ray, J., Sahoo, C. K., Mohanty, R., Sahoo, R., & Dalai, R. (2021). A review on diabetic peripheral neuropathy. Journal of Drug Delivery and Therapeutics, 11(2-S), 121-125. DOI: https://doi.org/10.22270/jddt.v11i2-S.4627

Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022). Inflammation in obesity, diabetes, and related disorders. Immunity, 55(1), 31-55. DOI: https://doi.org/10.1016/j.immuni.2021.12.013

Sartika, M. (2023). Faktor-Faktor Yang Berhubungan Dengan Prevalensi Diabetik Neuropati Periferal (DPN) Pada Pasien Dm Tipe II Di Indonesia: Associated Factors of The Prevalence of Peripheral Neuropathy Diabetic (DPN) Among DM Type II Patients in Indonesia. Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing), 9(2), 452-456. DOI: https://doi.org/10.33023/jikep.v9i2.1481

Sriyati, S. (2024). Neuropati diabetes sebagai faktor predisposisi terjadinya luka pada kaki. Jurnal Ilmiah STIKES Yarsi Mataram, 14(1), 46-52. DOI: https://doi.org/10.58184/jisy.v14i1.238

Sethi, Y., Uniyal, N., Vora, V., Agarwal, P., Murli, H., Joshi, A., ... & Kaka, N. (2023). Hypertension the ‘missed modifiable risk factor’for diabetic neuropathy: a systematic review. Current problems in cardiology, 48(4), 101581. DOI: https://doi.org/10.1016/j.cpcardiol.2022.101581

Sun, L., Zhang, X., Yang, J., Yuan, J., & Lei, X. (2024). Lower visceral fat is related to diabetic peripheral neuropathy. Diabetes, Metabolic Syndrome and Obesity, 2967-2974. DOI: https://doi.org/10.2147/DMSO.S469145

Suyanto, S., Millenniantary, U. F., & Noor, M. A. (2022). Analysis of Foot Sensation and Physical Activity in Diabetes Mellitus. Media Keperawatan Indonesia, 5(4), 274-279. DOI: https://doi.org/10.26714/mki.5.4.2022.274-279

Shillah, W. B., Yahaya, J. J., Morgan, E. D., & Bintabara, D. (2024). Predictors of microvascular complications in patients with type 2 diabetes mellitus at regional referral hospitals in the central zone, Tanzania: a cross-sectional study. Scientific Reports, 14(1), 5035. DOI: https://doi.org/10.1038/s41598-024-55446-y

Sunartini, N., Sina, M. I., Triwahyuni, T., & Fitriyani, F. (2023). Hubungan Antara Neuropati Diabetik Dengan Keseimbangan Fungsional Pada Pasien Diabetes Melitus Di Poli Klinik Rumah Sakit Pertamina Bintang Amin Bandar Lampung. Jurnal Ilmu Kedokteran Dan Kesehatan, 10(8), 2522-2530. DOI: https://doi.org/10.33024/jikk.v10i8.11306

Strand, N., Anderson, M. A., Attanti, S., Gill, B., Wie, C., Dawodu, A., ... & Maloney, J. A. (2024). Diabetic neuropathy: pathophysiology review. Current pain and headache reports, 28(6), 481-487. DOI: https://doi.org/10.1007/s11916-024-01258-w

Zhu, J., Hu, Z., Luo, Y., Liu, Y., Luo, W., Du, X., ... & Peng, S. (2024). Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment. Frontiers in endocrinology, 14, 1265372. DOI: https://doi.org/10.3389/fendo.2023.1265372

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